The Dichloroacetate Dilemma : Environmental Hazard vs . Therapeutic Goldmine – Both or Neither ?
نویسنده
چکیده
منابع مشابه
The Dichloroacetate Dilemma: Environmental Hazard versus Therapeutic Goldmine—Both or Neither?
BACKGROUND Dichloroacetate (DCA) is known to environmental scientists as a by-product of water chlorination and as a metabolite of industrial solvents, including Superfund chemicals. In contrast, DCA is studied by clinical investigators for its therapeutic potential in several life-threatening conditions, including genetic mitochondrial diseases, pulmonary arterial hypertension, and cancer. Thu...
متن کاملClinical pharmacology and toxicology of dichloroacetate.
Dichloroacetate (DCA) is a xenobiotic of interest to both environmental toxicologists and clinicians. The chemical is a product of water chlorination and of the metabolism of various drugs and industrial chemicals. Its accumulation in groundwater and at certain Superfund sites is considered a potential health hazard. However, concern about DCA toxicity is predicated mainly on data obtained in i...
متن کاملHuman Studies Involving DCA Use
Dichloroacetate (DCA), a stimulator of the pyruvate dehydrogenase complex, decreases lactate levels and peripheral resistance and increases cardiac output. This study was performed to examine the effects of DCA on exercise performance in humans. Eight healthy male volunteers (age 20–28 years) were tested by bicycle spiro-ergometry using a microprocessor-controlled gas analysis system after infu...
متن کاملAssessment of Salinity Hazard of Irrigation Water Quality in Monsoon Season of Batiaghata Upazila, Khulna District, Bangladesh and adaptation strategies
Batiaghata Upazila, Khulna District in south-west coastal region of Bangladesh is the mostly saline affected area, where agriculture activities are mainly dependent on rainfall. 23 water samples from surface water and shallow tube well (STW) were collected in the monsoon season and analyzed for physico-chemical properties to classify them according to salinity hazard. Electrical Conductivity (E...
متن کاملAssessment of Salinity Hazard of Irrigation Water Quality in Monsoon Season of Batiaghata Upazila, Khulna District, Bangladesh and adaptation strategies
Batiaghata Upazila, Khulna District in south-west coastal region of Bangladesh is the mostly saline affected area, where agriculture activities are mainly dependent on rainfall. 23 water samples from surface water and shallow tube well (STW) were collected in the monsoon season and analyzed for physico-chemical properties to classify them according to salinity hazard. Electrical Conductivity (E...
متن کامل